How Peptides Are Made

What does body building, anti-aging cream and Bleomycin (a cancer drug) have in common? Peptides of course! Peptides are large molecules that are vital to life. If you were to take a protein and break it into smaller pieces, each piece would be called a peptide. Just like proteins, peptides are made of amino acids linked together in a chain-like structure. Whenever you ingest a protein, your body breaks it down to its individual amino acids. It then puts those amino acids back together in a different order to make whatever peptide or protein your body needs. Insulin, for instance, …read more

Paul Jacob Evans


Synthetic Biology Creates Living Computers

Most people have at least a fuzzy idea of what DNA is. Ask about RNA, though, and unless you are talking to a biologist, you are likely to get even more handwaving. We hackers might have to reread our biology text books, though, since researchers have built logic gates using RNA.

Sometimes we read these university press releases and realize that the result isn’t very practical. But in this case, the Arizona State University study shows how AND, OR, and NOT gates are possible and shows practical applications with four-input AND gates and six-input OR gates using living cells. The …read more

Paul Jacob Evans

Stealing Joules From An Aluminium-Air Battery

While batteries are cheap and readily obtainable today, sometimes it’s still fun to mess around with their less-common manifestations. Experimenting with a few configurations, user [will.stevens] has assembled an aluminium-air battery and combined it with a joule thief to light an LED.

To build the air battery, soak an activated charcoal puck — from a water filter, for example — in salt-saturated water while you cut the base off an aluminium can. A circle of tissue paper — also saturated with the salt water — is pressed between the bare charcoal disk and the can, taking care not to …read more

Paul Jacob Evans

SCiO “Pocket Molecular Scanner” Teardown

Some of you may remember the SCiO, originally a Kickstarter darling back in 2014 that promised people a pocket-sized micro spectrometer. It was claimed to be able to scan and determine the composition of everything from fruits and produce to your own body. The road from successful crowdsourcing to production was uncertain and never free from skepticism regarding the promised capabilities, but the folks at [Sparkfun] obtained a unit and promptly decided to tear it down to see what was inside, and share what they found.

The main feature inside the SCiO is the optical sensor, which consists of …read more

Paul Jacob Evans

Anyone Need a Little Fuming Nitric Acid?

If there’s a chemical with a cooler name than “fuming nitric acid,” we can’t think of it. Nearly pure nitric acid is useful stuff, especially if you’re in the business of making rocket fuels and explosives. But the low-end nitric acid commonly available tops out at about 68% pure, so if you want the good stuff, you’ll have to synthesize fuming nitric acid yourself. (And by “good stuff”, we mean be very careful with the resulting product.)

Fuming nitric acid comes in two colors – red fuming nitric acid (RFNA), which is about 90% pure and has some dissolved nitrogen …read more

Paul Jacob Evans

Sort Out Chemical Storage For Your Shop

There is one constant in the world of hardware hacker’s workshops, be they a private workshop in your garage or a public hackspace, and it goes something like this:

Everybody’s a safety expert in whatever it is they are working with, right up until the accident.

In other words, it is very tempting to harbour a cavalier attitude to something that either you are familiar with or the hazards of which you do not understand, and this breeds an environment in which mishaps become a distinct possibility.

As hardware people, we are familiar with basic tool safety or electrical safety. …read more

Paul Jacob Evans

Go Small, Get Big: The Hack that Revolutionized Bioscience

Few people outside the field know just how big bioscience can get. The public tends to think of fields like physics and astronomy, with their huge particle accelerators and massive telescopes, as the natural expressions of big science. But for decades, biology has been getting bigger, especially in the pharmaceutical industry. Specialized labs built around the automation equipment that enables modern pharmaceutical research would dazzle even the most jaded CERN physicist, with fleets of robot arms moving labware around in an attempt to find the Next Big Drug.

I’ve written before on big biology and how to get more visibility …read more

Paul Jacob Evans