Synthesizing Daraprim to Beat Price Gougers

Drugs are used the world over to treat disease. However, from time to time, the vagaries of market economics, or unscrupulous action, can radically increase the price of otherwise cheap pharmaceuticals far beyond the reach of the average person. This was the case with Pyrimethamine (sold as Daraprim), which is used to treat toxoplasmosis and malaria, among other users. With the price skyrocketing from $13 to $750 a tablet in the US in 2015, [NurdRage] decided to synthesize the drug on their own. (If you missed the background hubbub, search for “Martin Shkreli”.)

The video linked covers the final synthesis, …read more

Paul Jacob Evans


Flying Defibrillators

It’s a sad reality that, by and large, cardiopulmonary resuscitation (CPR) doesn’t save lives. Despite all the “you could save a life” marketing aimed at getting people certified in CPR, the instances where even the prompt application of the correct technique results in a save are vanishingly rare, and limited mostly to witnessed arrests in a hospital. Speaking from personal experience, few things are sadder than arriving on-scene as a first responder to see CPR being performed by a husband on his wife and knowing that no matter what we do, it’s not going to end well.

The problem is …read more

Paul Jacob Evans

Using A Thermal Camera To Spot A Broken Wrist

Chemist and Biochemist [Thunderf00t] has shown us a really interesting video in which you can spot the wrist he broke 10 years ago using a thermal camera.

He was on an exercise bike while filming himself on a high-resolution thermal camera, As his body started to heat up he noticed that one hand was not dumping as much heat as the other. In fact one was dumping very little heat. Being a man of science he knew there must be some explanation for this. He eventually came to the conclusion that during a nasty wrist breaking incident about 10 years …read more

Paul Jacob Evans

Go Small, Get Big: The Hack that Revolutionized Bioscience

Few people outside the field know just how big bioscience can get. The public tends to think of fields like physics and astronomy, with their huge particle accelerators and massive telescopes, as the natural expressions of big science. But for decades, biology has been getting bigger, especially in the pharmaceutical industry. Specialized labs built around the automation equipment that enables modern pharmaceutical research would dazzle even the most jaded CERN physicist, with fleets of robot arms moving labware around in an attempt to find the Next Big Drug.

I’ve written before on big biology and how to get more visibility …read more

Paul Jacob Evans

MRIs: Why Are They So Loud?

My dad was scheduled for his first MRI scan the other day, and as the designated family technical expert, Pop had plenty of questions for me about what to expect. I told him everything I knew about the process, having had a few myself, but after the exam he asked the first question that everyone seems to ask: “Why is that thing so damn loud?”

Sadly, I didn’t have an answer for him. I’ve asked the same question myself after my MRIs, hoping for a tech with a little more time and lot more interest in the technology he or …read more

Paul Jacob Evans

Radio Controlled Pacemakers Are Easily Hacked

Doctors use RF signals to adjust pacemakers so that instead of slicing a patient open, they can change the pacemakers parameters which in turn avoids unnecessary surgery. A study on security weaknesses of pacemakers (highlights) or full Report (PDF) has found that pacemakers from the main manufacturers contain security vulnerabilities that make it possible for the devices to be adjusted by anyone with a programmer and proximity. Of course, it shouldn’t be possible for anyone other than medical professionals to acquire a pacemaker programmer. The authors bought their examples on eBay.

They discovered over 8,000 known vulnerabilities in third-party libraries …read more

Paul Jacob Evans

Measuring Walking Speed Wirelessly

There are a lot of ways to try to mathematically quantify how healthy a person is. Things like resting pulse rate, blood pressure, and blood oxygenation are all quite simple to measure and can be used to predict various clinical outcomes. However, one you may not have considered is gait velocity, or the speed at which a person walks. It turns out gait velocity is a viable way to predict the onset of a wide variety of conditions, such as congestive heart failure or chronic obtrusive pulmonary disease. It turns out, as people become sick, elderly or infirm, they tend …read more

Paul Jacob Evans